Experimental data demonstrate that GATA-3-specific DNAzymes do not lead to unspecific immune cell activation

Marburg, Germany, 27 March 2012 

  • Results support favourable safety profile observed in toxicological studies and in recently completed first clinical trial of SB010

A paper published in Nucleic Acid Therapeutics (Dicke et al., 2012) found that the DNAzyme used in sterna biologicals’ drug candidate SB010, a novel inhaled GATA-3 antagonist for the treatment of moderate to severe Th2-driven asthma, does not lead to unspecific immune cell activation.

sterna biologicals completes first-in-man study of SB010

Marburg, Germany, 27 February 2012

  • sterna biologicals completes first-in-man study of SB010, an inhaled GATA-3 antagonist for the treatment of moderate to severe Th2-driven asthma
  • SB010 was safe and well-tolerated across all dose levels

sterna biologicals GmbH & Co. KG (“sterna biologicals”) is pleased to announce successful completion of a Phase I clinical trial of its novel inhaled GATA-3 antagonist SB010 for the treatment of moderate to severe Th2-driven asthma.

sterna biologicals commences phase I clinical trial of first-in-class DNAzyme-based GATA-3 antagonist for the treatment of moderate to severe Th2-driven asthma

Marburg, Germany, 07 November 2011

sterna biologicals GmbH & Co. KG ("sterna biologicals") is pleased to announce first dosing of its novel inhaled GATA-3 antagonist SB010 for the treatment of moderate to severe Th2-driven asthma in a phase I clinical trial. The trial is a randomised, double-blind, placebo-controlled assessment of safety and tolerability of single ascending doses of SB010 in 48 male subjects conducted by CRS Clinical Research Services Mannheim GmbH in Mannheim, Germany.